Relationship between endothelial protein C receptor gene 6936A/G polymorphisms and deep venous thrombosis / 中华血液学杂志

<p><b>OBJECTIVE</b>To investigate the relationship between endothelial protein C receptor(EPCR) gene 6936A/G polymorphism and deep vein thrombosis (DVT).</p><p><b>METHODS</b>The study group included 65 DVT patients and 71 normal controls. Plasma sEPCR was measured by ELISA. Genomic DNA was extracted by using Genomic Purification Kit. A 315bp EPCR product was amplified by a standard PCR reaction, and the bands were confirmed by direct sequencing after purification.</p><p><b>RESULTS</b>(1) sEPCR levels in healthy controls with 6936AG genotype were significantly higher than that in those with 6936AA genotype \[(0.97 ± 0.32) ng/L vs (0.61 ± 0.24) ng/L, P < 0.01)\], and so did in DVT patients \[(0.87 ± 0.21) ng/L vs (0.50 ± 0.18) ng/L, P < 0.01\]. (2) The sEPCR levels of DVT patients \[(0.68 ± 0.32) ng/L\] were significantly higher than that of healthy controls \[(0.54 ± 0.22) ng/L\](P < 0.05). (3) The distribution of 6936A/G genotype was higher in DVT patients than in healthy controls (P < 0.05). (4) Subjects with 6936A/G had an increased risk of thrombosis (OR = 2.75, 95%CI = 1.04 - 7.30) (P < 0.05).</p><p><b>CONCLUSIONS</b>EPCR gene 6936A/G polymorphism is associated with increased plasma sEPCR levels. The sEPCR levels in DVT patients were significantly higher than that in healthy controls. The subject with 6936AG likely had an increased risk of thrombosis.</p>

Treatment of the infrequent complications after stent graft placement for aortic disease / 中华外科杂志

<p><b>OBJECTIVE</b>To explore the infrequent complications and treatment after endoluminal stent graft implantation for aortic diseases.</p><p><b>METHODS</b>Review of the characters and complications for five cases of aortic diseases by stent graft implantation.</p><p><b>RESULTS</b>The complications of 4 cases have been relieved by operation or re-stent implantation, 1 case was died.</p><p><b>CONCLUSION</b>The complications are difficult to forecast for stent graft placement in aortic diseases, the surgeon should be well practiced in surgical and interventional technique, so as to treat the complications in time.</p>

Exploration on endovascular treatment for disorders of great vessels / 中华外科杂志

<p><b>OBJECTIVE</b>To explore the efficacy and shortcoming of endovascular therapy with mainly endovascular graft in treating disorders occurring in the thoracic or thoracoabdominal aorta.</p><p><b>METHODS</b>Total 137 cases with great vessel disorders including dissections, aneurysm, pseudoaneurysm, aortic deceleration injury and coarctation were treated by endovascular technique. The lowest lesion located between the celiac and mesenteric arteries.</p><p><b>RESULTS</b>Two cases underwent emergent surgery due to acute visceral arterial insufficiency. Seven cases had early endoleaks. After a follow-up of 1 - 43 (average of 11) months, 2 late endoleaks were detected; 5 patients died, 4 of them were due to endograft unrelated diseases, one due to a recurrent multiple aneurysms.</p><p><b>CONCLUSION</b>Endovascular treatment is relatively safe and effective for treating high risky patients with lesions occurring in the great vessels and seems to have a prospective future, although the device needs to be further improved and the long-term efficacy should be confirmed.</p>